Pair Name	Glaucocalyxin B, Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Induced-->Oxidative Stress
Gene Regulation	Up-regulation	Phosphorylation	MAPK8	hsa5599
In Vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0134
	A2780/CDDP	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_D619
Result	GLB enhances the sensitivity of ovarian cancer cells to cisplatin via increasing reactive oxygen species (ROS) levels, the phosphorylation of c-Jun N-terminal kinase (JNK), and DNA damage. A synergistic inhibitory effect of GLB with cisplatin was also observed in the cells which were resistance to cisplatin. These data suggest that GLB can sensitize ovarian cancer cells to cisplatin by increasing ROS levels.